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Results for "

SK-BR-3 cells

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

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Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150401
    Exatecan-amide-cyclopropanol

    		ADC Cytotoxin Topoisomerase Cancer
    Exatecan-amide-cyclopropanol (compound 1) is a anticancer agent. Exatecan-amide-cyclopropanol shows anti-proliferation activity against SK-BR-3 and U87 cells, with IC50 values of 0.12 and 0.23 nM, respectively .
    Exatecan-amide-cyclopropanol
  • HY-156617A
    (αR)-Cyclopropaneacetamide-Exatecan

    		ADC Cytotoxin Topoisomerase Cancer
    (αR)-Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, is a cytotoxic agent. (αR)-Cyclopropaneacetamide-Exatecan inhibits U87MG and SK-BR-3 cells proliferation, with IC50s of 8.11 and 2.31 μM .
    (αR)-Cyclopropaneacetamide-Exatecan
  • HY-153588
    HSP90-IN-22

    		HSP Cancer
    HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.
    HSP90-IN-22
  • HY-160282
    PI3K-IN-49

    		PI3K Cancer
    PI3K-IN-49 is a potent PI3K inhibitor. PI3K-IN-49 shows antiproliferative activity for Avg T-47D and Avg SKBR3 cells (WO2023239710A1; example 29) .
    PI3K-IN-49
  • HY-144808
    Anticancer agent 40

    		Others Cancer
    Anticancer agent 40 (compound 3e) is a potent anticancer agent. Anticancer agent 40 shows anticancer activities with IC50s of 0.94, 0.98, 0.96, 0.95, 2.13 nM for SKBR-3, SKOV-3, PC-3, U-87, HDF cells, respectively .
    Anticancer agent 40
  • HY-124386
    DBCO-NHCO-PEG4-amine

    		ADC Linker PROTAC Linkers Cancer
    DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) .
    DBCO-NHCO-PEG4-amine
  • HY-124007
    4-Iodo-SAHA

    ISAHA

    		 HDAC Cancer
    4-Iodo-SAHA (1k) is an orally active class I and class II histone deacetylase (HDAC) inhibitor with EC50s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM for Skbr3, HT29, U937, JA16 and HL60 cell lines, respectively. 4-Iodo-SAHA (1k) can be used for the research of cancer .
    4-Iodo-SAHA
  • HY-151118
    HER2-IN-11

    		Apoptosis Cancer
    HER2-IN-11 is a psoralen derivative. HER2-IN-11 has anti-breast cancer activity and light-activated cytotoxicity. HER2-IN-11 induces apoptosis .
    HER2-IN-11
  • HY-151116
    HER2-IN-10

    		Apoptosis Cancer
    HER2-IN-10 is a psoralen derivative. HER2-IN-10 has anti-breast cancer activity and light-activated cytotoxicity. HER2-IN-10 induces apoptosis .
    HER2-IN-10
  • HY-151335
    KU-177

    		HSP Cancer
    KU-177 is a potent inhibitor of Hsp90 ATPase homologue 1 (Aha1), ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation. KU-177 also disrupts Aha1/Hsp90 interactions (IC50=4.08 μM) without inhibition of Hsp90’s ATPase activity. KU-177 can be used for tauopathies research .
    KU-177

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